B12 shots are often just as effective as supplements. Some research has found supplements in the form of prescription pills to be more affordable, and people with an aversion to needles may prefer to receive their doses as pills. On the other hand, pills must be taken more frequently than a monthly shot, so some people may prefer the latter to remembering to take a supplement. Plus, people who have digestive issues that reduce the absorption of vitamin B12 may get more benefits from an injection.

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