The dense nutrient load of butternut squash may pose risks for some individuals. People who use beta-blockers, ACE inhibitors, diuretics, or other medications that increase potassium levels in the blood should consume butternut squash in moderation to avoid developing hyperkalemia (too much potassium). People with kidney disorders may consume butternut squash, but they should also exercise caution when eating foods high in potassium: a buildup of potassium in the blood could be fatal.

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