Possible Medical Causes of Cold Feet

5. Adrenal Insufficiency

According to the American College of Foot and Ankle Surgeons, cold feet may be a symptom of an adrenal deficiency. The two adrenal glands above the kidneys produce cortisol and work with the pituitary and hypothalamus glands in the brain. Cortisol helps regulate blood pressure and the immune system. Primary adrenal insufficiency or Addison's disease is a rare condition caused by damage to the adrenal glands. It can also stem from cancer, inherited endocrine gland disorders, and fungal infections. Most commonly, it is caused by an autoimmune condition. Secondary adrenal insufficiency occurs due to dysfunction of the pituitary gland. This condition may arise from pituitary gland tumors or removal of the pituitary or hypothalamus gland. Certain medications, including anabolic steroids and corticosteroids, can also trigger adrenal insufficiency.