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4. Buerger's Disease

Using tobacco products is strongly associated with Buerger's disease, which causes blood vessels to swell and become inflamed. This impedes blood flow and leads to clot formation. Advanced cases result in tissue damage and gangrene. Researchers hypothesize that Buerger's disease is due to chemicals in tobacco that irritate and inflame the lining of blood vessels. The most common symptoms include cold, severe pain, and bluish or red discoloration in the hands or feet. Some people also develop sores in these areas that may become infected due to reduced blood flow. Quitting smoking can help ease symptoms.

Possible Medical Causes of Cold Feet sestovic / Getty Images

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