A government multi-ethnic population study correlated vitamin K deficiency with chronic kidney disease. Another clinical trial concluded that most people who undergo dialysis do not get enough of the micronutrient. The vitamin is a catalyst for biological processes that inhibit vascular mineralization. Low levels appear to play into the development of calciphylaxis, the accumulation of calcium in small blood vessels of skin and fat tissues, including kidney tissue. Vitamin K supplementation shows potential for reducing this buildup in individuals with renal failure.

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