The circadian rhythm influences metabolic, neuronal, endocrine, and behavioral functions. Our internal clocks run in key tissues such as the pancreas, liver, skeletal muscle, and white adipose. Chrononutrition, a developing field of scientific study, explores how nutrition interacts with circadian rhythms. Time Restricted Eating (TRE) methods such as the 16:8 diet is one way scientists are applying chrononutrition to dietary health. Animal studies suggest TRE can reduce the risk of metabolic diseases and obesity. Human studies produce varying results; nonetheless, increasing evidence supports the possibility that TRE can positively impact metabolism.

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