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5. Cause: Platelets Trapped in the Spleen

The spleen plays an important role in immune system function, storing platelets and filtering the blood. Sometimes, platelets get trapped in the spleen and are unable to circulate, reducing the available platelet count and resulting in thrombocytopenia. An enlarged spleen can be a sign of immune system problems that could affect blood clotting.

Thrombocytopenia causes decade3d / Getty Images

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