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6. Cause: Platelet Destruction by the Immune System

Autoimmune conditions such as lupus can turn the body's defenses against platelets, destroying available clotting ability and causing bleeding problems. Certain rare conditions and medications such as some anticoagulants and antibiotics can induce an autoimmune response against platelets, as can certain viral infections such as HIV.

Thrombocytopenia Zerbor / Getty Images

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