A notable percentage of people with Isaacs’ syndrome have a tumor on the thymus gland or thymoma. Normally, the thymus gland sits between the lungs and is only active until puberty. When it activates, the thymus gland is the source of many specialized cells with autoimmune functions. Because of this, thymoma has links to myasthenia gravis and many other autoimmune diseases. The tumor itself can cause chest pain and cough.

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