Understanding the Effects of Isaacs' Syndrome

5. Causes of Isaacs' Syndrome

Doctors and researchers currently do not know what specifically causes Isaacs’ syndrome, though they can categorize the disease by underlying cause. The three categories are acquired, paraneoplastic, and hereditary. Of these, the acquired form is most common, making up almost 80% of cases. Current theories point to the acquired form being the result of antibodies affecting the neuromuscular junction. Specifically, antibodies bind to potassium channels on the motor nerve, which results in muscle hyper-excitability.