In some cases, lupus disturbs the function of the thyroid, which produces hormones that determine the body's metabolic rate. The most common symptoms stemming from damage to the thyroid are changes in metabolism due to thyroid hormone fluctuations. Some people with lupus experience sudden weight gain or loss. Other signs of thyroid malfunction are dry skin, dry hair, constipation, depression, sensitivity to cold, fatigue, and mood swings.

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