Malaise is an often-misused term. The non-specific symptom presents with a variety of diseases and illnesses and is hard to define: essentially, it is a feeling of pain or uneasiness or that something is just not right. The severity of malaise depends on the cause. It ranges from mild to serious, and some experts believe it is caused by activation of the immune response.
Malaise is often confused with fatigue. Though the two can occur simultaneously, they are distinct symptoms. Malaise is a general feeling of discomfort that is non-specific and can be hard to explain. It can occur with just about any health condition. Fatigue is the physical feeling of not having any energy. Further, fatigue differs from tiredness or exhaustion in that rest may not alleviate it.
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