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7. Causes and Risk Factors

Doctors and researchers have not identified what causes CREST syndrome. The prevailing theory presumes autoimmune anti-nuclear and anti-centromere antibodies, which stimulate the production of too much collagen, are a factor. Females are more at risk of developing CREST syndrome, as are people between the ages of 30 and 50.

researcher microscope antibody dra_schwartz / Getty Images

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