Polyautoimmuity is having more than one autoimmune disease. When someone has three or more autoimmune diseases at the same time, they have multiple autoimmune syndrome. People with polyautoimmunity may develop diseases that stem from a common genetic root. One study found that 34.4 percent of autoimmune patients have polyautoimmunity; Sjögren's syndrome and autoimmune thyroid disease was the most common pair.

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