Non-Hodgkin lymphoma sometimes causes red or purple lumps and itchy skin. When the tumor starts in the skin, the manifestations tend to differ according to the type of malignant lymphocyte involved; it can either be a T-cell lymphocyte or a B-cell lymphocyte.
T-cell lymphoma skin lesions include flat red patches, thick, raised plaques, and sometimes the skin of the palms and soles becomes thickened. B-cell lymphoma skin lesions present as a reddish rash or nodules with a raised smooth surface. These lesions can become infected or develop ulcers.

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