Non-Hodgkin lymphoma can leave people feeling exhausted and weak. This feeling can come on during or after physical activity, but it can also be unrelated. Patients may feel unable to carry out regular daily tasks, and their energy often is not restored after resting or sleeping.
This symptom may be due to the presence of the lymphoma, which drains the body's energy sources or releases harmful proteins or cytokines the body must fight. It can also be due to stress, anxiety, lack of sleep, or anemia. Fatigue caused by cancer can last for years and may persist even after treatment.

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