The most common way to diagnose ampullary cancer is with an endoscopy. The doctor runs a long, thin tube equipped with a camera through the intestinal tract to view any duct blockages. Endoscopies may also collect tissue from the ampulla of Vater, which lab technicians will test for cancer cells. Blood and urine tests can identify cancer markers as well. Some doctors also order imaging scans such as ultrasounds or MRIs to search for signs of a tumor.

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