In myelofibrosis, the tissue that forms blood cells is replaced by collagen fibrous tissue. This will decrease the bone marrow's ability to produce new blood cells. Some of these affected cells are red blood cells. This is why the person who suffers from Myelofibrosis can develop anemia. The decrease in the number of available red blood cells will cause many other symptoms as well. Fatigue is one of them because red blood cells are responsible for delivering oxygen to all of the cells in the body. When the numbers of red blood cells decrease, the different cells of the body will not be able to find an adequate amount of oxygen that it needs to produce energy. So, the person will feel tired and exhausted all the time.
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