One of the stranger symptoms of esophageal cancer is frequent hiccups. These natural and involuntary contractions of the diaphragm usually occur following meals or certain beverages. However, when they happen frequently over a long period, they can signify a serious medical issue. Esophageal cancer can spread from the esophagus into the vagus or phrenic nerves that serve the diaphragm. As cancer worsens, the hiccups become more common.

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