Stage 4 is considered late-stage colorectal cancer. At this point, the cancer can spread to other parts of the body, and substages refer to the number of distant organs affected. If colon cancer spreads to the liver, for example, the liver will have colon cancer cells. In addition to symptoms from earlier stages, individuals may present with jaundice, swollen hands and feet, breathing difficulties, chronic headaches, blurry vision, pelvic pain, and anemia. Symptoms at this stage are also related to affected organs.
For example, if cancer spreads to the liver, itchy skin may be an issue, and the abdomen may appear swollen, and if it spreads to the bones, fractures may occur.

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