Bone cancer affecting the bone marrow may cause anemia, the lack of a healthy level of red blood cells or hemoglobin. Cancer interferes with the production of red blood cells, and low levels of hemoglobin prevent the body from getting the oxygen it needs. Symptoms of anemia include fatigue and weakness, shortness of breath, headaches, chest pains, irregular heartbeats, and lightheadedness. A physician can test for red blood cell levels using a complete blood count (CBC) test.

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