Untreated bladder cancer will metastasize to other parts of the body, commonly the liver, lungs, and bones. Worsening signs and symptoms of bladder cancer are often evidence of metastasis. Signs of metastasis also depend on the areas to which the cancer has spread. Liver cancer causes abdominal swelling and jaundice; a persistent cough and trouble breathing may indicate lung cancer. Bone cancer leads to weak and fragile bones that break easily and bone pain.

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