Complex purine metabolism failures can also cause hyperuricemia. Certain enzymes play central roles in the metabolism and breakdown of purines. If there is a deficiency of one of these enzymes, such as hypoxanthine-guanine phosphoribosyltransferase (HGPRT), then the body will overproduce uric acid. Overactivity of phosphoribosyl pyrophosphate (PRPP) can cause similar issues. Both of these problems are symptoms of Lesch-Nyhan Syndrome.

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