Several medications and vitamins tend to cause hyperuricemia. Diuretics prompt the kidneys to release more sodium into the urine. This draws excess water from the blood, leading to lower blood pressure and an increase in urination. However, because the body is losing fluid, the concentration of the remaining fluid increases. As a result, uric acid levels that were once healthy become dangerously high. Certain vitamins, such as B3, can also lead to high uric acid levels.

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