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5. Paget’s Disease

Normally, new bone tissue slowly replaces old bone tissue as part of the body’s recycling process. Paget’s disease interferes with this process and can cause bones to become fragile or misshapen. Though researchers do not yet understand the relationship, people with active Paget’s disease tend to have higher uric acid levels. Some studies suggest that Paget’s disease may be causing metabolic issues that then lead to excess purine breakdown.

pagets disease bone tissue xray HRAUN / Getty Images

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