Increasing age is a factor in the development of Heberden’s nodes. It is rare for Heberden’s nodes to form before the age of 40 unless the person has osteoarthritis caused by a joint injury. Women most often develop Heberden’s nodes after the onset of menopause, while they begin to appear in men during middle age. Doctors diagnose about half of the individuals with Heberden’s nodes before 65.

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