Doctors do not know the exact cause of Grover's disease, but they have identified some contributing factors. Organ transplantation, x-ray exposure, and kidney failure may contribute, along with antiviral medications and biologic agents. Prolonged exposure to hot water bottles, electric blankets, and hot tubs seem to play a role, as does prolonged bed rest. Heat, sweating, and sunlight can bring on or exacerbate the symptoms.

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