Uremia is the build-up of toxic urea in the blood, which can cause nausea, vomiting, inflammation, and ulcers in the gastrointestinal system, as well as a slowing down of digestion or gastroparesis. These gastrointestinal symptoms can cause severe malnutrition with subsequent fat and muscle loss. Malnutrition can also lead to vitamin deficiencies with other symptoms such as bone loss and secondary hypoparathyroidism.

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