While an enlarged heart is nearly always treatable, complications may arise if the individual does not take medications as prescribed or has not made lifestyle changes essential for supporting heart health. Heart failure is the most serious complication, followed by blood clots and sudden death. Cardiomegaly facilitates the formation of blood clots in the heart's lining. If just one clot becomes dislodged and enters the bloodstream, it could travel to a vital organ and cause a stroke or heart attack. Heart murmurs may occur if the heart's valves do not close properly; the noise is the sound of blood flowing back into the heart.

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