Acetaminophen can cause liver damage at high doses. There is a higher risk of liver damage if people take acetaminophen in combination with other medications that impact the liver. The medicine should never be combined with alcohol, as this significantly increases liver toxicity. Ibuprofen can cause decreased blood coagulation, so people with blood coagulation disorders should take care. Ibuprofen decreases blood flow to the kidneys, so long term use can increase kidney disease. Taking ibuprofen with alcohol can increase the risk of gastric bleeding. Also, ibuprofen may increase sun sensitivity.

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