When taken correctly, acetaminophen has few side effects. Nausea, headache, insomnia, and fatigue can occur but are rare. Ibuprofen, however, has several side effects. Most notable are gastric problems such as nausea, acid reflux, diarrhea, and constipation. Repeated use of ibuprofen can cause stomach ulcers and it may increase shortness of breath in people with asthma.

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