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4. Fresno, California

Fresno is agricultural, but unemployment and poverty levels are significant, most of the town's residents lack a college degree to break the cycle, and 22 homicides occurred in 2021. There's also the fact that Fresno has a high rate of asthma-related deaths. Wildfires have exacerbated existing air pollution, so if you're sensitive to air quality, you'll want to steer clear of this city.

 Van Ness Avenue Entrance to Downtown Fresno, California, USA. "The Best Little City in the U.S.A."

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