Dogo Argentinos shed lightly and lack a strong doggy smell. A quick brush each week and a bath, when they get dirty, is all that is needed to keep them looking clean and smelling fresh. They have strong nails that grow quickly, so owners need to keep them trimmed to prevent breakage. As puppies, they benefit from specific large-breed puppy food, as this helps them grow slowly and prevents the development of joint problems. Adults should have a diet that supports their high level of activity.

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