The Dogo Argentino was developed in the Cordoba region of Argentina by Dr. Antonio Nores Martinez. He bred several breeds including mastiffs with the local old fighting dog of Cordoba, a breed which is now extinct. Dr. Nores Martinez took his dogs hunting with him, where they quickly demonstrated their skill at bringing down big game such as wild boars and pumas. He then concentrated on bringing out their fearlessness and the ability to navigate Argentina's terrain.

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