In large amounts or in people with sensitivities, citric acid could induce numbness, swelling, rapid weight gain, cramps, mood changes, and muscle twitching. Citric acid supplements or medications might interact with diuretics, antacids, or heart or blood pressure medications. Ideally, everyone should speak to a doctor before making significant changes to their diets. This is especially essential for people with a medical history of the following conditions:

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