Small studies on rats have discovered a few possible interactions between nightshade vegetable alkaloids and certain diseases. Several research groups found that alkaloids increased intestinal inflammation in rats with inflammatory bowel disease. Nightshades may also aggravate symptoms of conditions of celiac disease, rheumatoid arthritis, and multiple sclerosis.
Keep in mind, however, that these studies often use far higher doses of alkaloids than are present in the vegetables themselves, and these findings have not been confirmed in humans.

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