People with diabetes may develop microangiopathy or small vessel disease. Microangiopathy causes leakage from capillaries that can result in skin ulceration, especially in the lower legs and feet. Bioactive compounds in gotu kola can relieve this condition in several ways. Triterpenes reduce fluid leakage by strengthening blood vessels and improving microcirculation. The same compounds promote healing of the ulcers themselves, and gotu kola's effects on blood glucose levels may help manage diabetes.

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