No specific medication is approved for mpox. Treatment currently focuses on comfort and symptom management. People with active mpox infections should remain isolated, wear a mask, and cover lesions with gauze or bandages until healed. Scratching the lesions or shaving the area can spread the virus to other body parts or introduce new infection-causing bacteria. Acetaminophen can provide pain relief, and prescription mouthwashes may be necessary to treat pain if the rash appears in the mouth. Oral antihistamines can help with other symptoms.
Researchers are looking at investigational smallpox drugs like TPOXX as possible treatments for mpox, but these antivirals are currently only considered for people with severe cases and weakened immune systems.

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