Understanding and Managing Mpox (Monkeypox)

6. Diagnosis

Mpox is generally rare, so healthcare professionals may first rule out other rash-producing infections like syphilis, chickenpox, and measles if the person does not live in an area with significant exposure risk. They may use blood tests or swabs from the rash to confirm a diagnosis. Some countries utilize tests that can only detect Clade I or Clade IIb, which can lead to missed diagnoses. The FDA has approved a test that can detect all versions of mpox but not the specific type in a particular individual. A positive result would necessitate further testing to clarify the clade.