Usually, the incubation period following a tick bite is between one and two weeks. Most tick bites are painless, and few people realize they were bitten. Though asymptomatic infection is possible, early symptoms include fever, chills, headaches, muscle aches, and stomach issues such as vomiting, diarrhea, and nausea. If a person does not receive treatment or if they have other medical conditions, anaplasmosis may lead to serious illness, with symptoms such as respiratory failure, organ failure, bleeding issues, and even death. Older individuals and people with weaker immune systems are particularly at risk for life-threatening complications.

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