Understanding the Effects of Isaacs' Syndrome

8. Peripheral Nerve Hyperexcitability

Because of the rarity of the condition and the diagnostic difficulties, some doctors choose not to diagnose Isaacs’ syndrome specifically. Instead, they refer to a group of symptoms as “peripheral nerve hyperexcitability.” Within this umbrella term are disorders like benign fasciculation syndrome, Morvan’s syndrome, cramp fasciculation syndrome, and Isaacs’ syndrome. The differences between these conditions are often merely a matter of severity, and diagnosis is often largely subjective.