One of the main difficulties of diagnosis is that Isaacs’ syndrome mimics symptoms of many other, significantly more dangerous, diseases. Some of its symptoms resemble those of motor neuron diseases such as amyotrophic lateral sclerosis or ALS. Occasionally, doctors misdiagnose Isaacs’ syndrome as multiple sclerosis. Because the symptoms can point to many dangerous disorders, and doctors want to make sure they make the right diagnosis, the process is often emotionally exhausting and stressful for patients.

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