Alongside the main muscle symptoms, Isaacs’ syndrome has a variety of other effects. Many people have ataxia or difficulty walking because they cannot coordinate voluntary muscle movements. They may also develop balance issues. Excessive sweating or hyperhidrosis is common. Isaacs’ syndrome most prominently affects the trunk, legs, face, and neck, though it can affect many other muscles and body parts. Notably, it tends not to influence cardiac and smooth muscles. Symptoms may range from inconvenient to debilitating and chronically improve or worsen.
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