12 Signs and Symptoms of Lymphoma

8. Itching

As lymphoma cells multiply and become more potent, they secrete chemical by-products called cytokines that irritate the nerves in the skin. This leads people with the condition to feel itchy in localized areas or all over the body, for no apparent reason. In rare instances, papules, acne-like clusters, develop in the areas most impacted by cancer. Typically, though, there are no visible signs of skin irritation. Topical creams and ointments may provide temporary relief, but there is no long-term respite since the chemicals are released directly into the bloodstream.