Post-treatment Lyme disease syndrome (PTLD) occurs when people are treated with a full course of antibiotics that lasts from two to four weeks and still have symptoms like brain fog, pain, and fatigue for more than six months after finishing treatment. The cause of PTLD is unknown, but some researchers believe it is caused by either a persistent infection that's difficult to detect or an autoimmune response.
There are no known treatments for PTLD. Prolonged antibiotics were not effective in studies. Symptoms usually improve over time, but recovery can take months.

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