As the number of red blood cells decreases, the cells in the brain do not get an adequate amount of oxygen they need for various functions. This makes the person affected with acute myeloid leukemia feel dizzy and lightheaded. Many patients may find it hard to focus, concentrate or perform challenging mental activities. They may also experience breathing difficulties in the form of shortness of breath. This shortness of breath becomes more apparent when the person tries to perform physical activity. Again, a decreased number of red blood cells can also cause this symptom.

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