CREST syndrome’s most observable symptom is sclerodactyly, a condition that causes thickening of the skin of the fingers. Only the tips and middles of the fingers thicken in most cases. Early in the process, the skin may look inflamed or like fluid is building up. As the issue progresses, collagen deposits accumulate, making the skin tighten and harden. Between 30 and 50% of patients also develop ischemic ulcers in their fingers.

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