One of the rarest conditions affecting the pituitary gland is hypophysitis or inflammation of the gland. Since the condition is so rare, medical experts do not fully understand it. Initial symptoms are often headaches and vision issues. Depending on how it affects hormones, other symptoms can occur. Polyuria and polydipsia — which refer to excess urination and extreme thirst, respectively — are common. Doctors often discover hypophysitis when searching for a pituitary adenoma.

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