Deciding whether to be tested for factor V Leiden is a personal decision. If several people in a woman's family have experienced problems with blood clots, then it may help with decisions as to the type of birth control or hormone replacement therapy she chooses. Conversely, if one has no symptoms and leads a relatively healthy lifestyle, a positive test result may create additional anxiety or affect health insurance coverage. For people with a single F5 gene mutation, the chances of developing a blood clot are fairly low.

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