Diabetic Foot Pain: What Causes it and What Does it Mean?

5. Gangrene

A combination of poor blood circulation and peripheral neuropathy can lead to gangrene, a condition that occurs when body tissue dies. Usually, this is the result of reduced blood flow, an infection, or an injury. People with diabetes have a much higher risk of developing gangrene. As the infection worsens and tissues die, gangrene can become a life-threatening condition. Any sign of tissue death requires immediate medical attention. Signs of gangrene include purple, green, or black skin, severe pain, foul smell, and skin lesions.